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Human breast cancer is a heterogeneous disease consisting of multiple molecular subtypes. Genetically engineered mouse models are a useful resource for studying mammary cancers in vivo under genetically controlled and immune competent conditions. Identifying murine models with conserved human tumor features will facilitate etiology determinations, highlight the effects of mutations on pathway activation, and should improve preclinical drug testing.

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Chemotherapy plays an important role in the management of metastatic breast cancer. The anthracyclines doxorubicin, epirubicin and the taxanes paclitaxel, docetaxel are considered the most active agents for patients with advanced breast cancer. The taxanes have single-agent activity similar to older combination chemotherapy treatments.

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Skip to search form Skip to main content. Implications for breast cancer treatment from increased autotaxin production in adipose tissue after radiotherapy. Hemmings and Frank R.


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